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  • Deleted User

    Deleted User
    July 29, 2021 at 3:19 pm

    This is where it gets interesting;

     

    ” If an antisense oligonucleotide drug, which stops cells from manufacturing specific proteins, was used to decrease the amount of CHMP7 within the ALS neurons, the pore never degraded. “

  • richardhasals

    Member
    July 30, 2021 at 11:37 am

    If past history of so-called ALS treatment breakthroughs are any indication of any possible future ALS treatments, then this too will fizzy out into obscurity.

     

    Richard

     

    • jean-pierre-le-rouzic

      Member
      July 30, 2021 at 2:05 pm

      Dr. Rothstein works in ALS research since a long time (~20 years?). But what is presented here is not very impressive. Working with iPSC-derived is something that could be done at little cost now, and (fortunately) many teams are working on ways to mitigate TDP-43 aggregates.
      And it only pushes the goal post further away: What makes CHMP7 aggregate in the nucleus?

      I guess this work has two objectives:
      1. Participating in the run to patent TDP-43 therapies.
      2. Showing to funding parties that the lab is doing something with their money.

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