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Darifinacin?
Darifinacin is an approved over-active bladder medicine (available as a generic) that is currently being investigated in a Phase 2 clinical trial for its potential to treat amyotrophic lateral sclerosis (ALS). The two trial sites are in Montreal (NCT06249867). The drug is being repurposed
based on preclinical research suggesting it may improve the function of
neuromuscular junctions (NMJs), which are connection points between
nerves and muscles. Since it is FDA approved, is anyone taking it “off-label” for ALS? If so, what has been your experience?
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