FightMND Awards Grant to Lauren Sciences to Develop Promising ALS Therapy

FightMND Awards Grant to Lauren Sciences to Develop Promising ALS Therapy
0
(0)

The Australian non-profit organization FightMND has awarded Lauren Sciences a AU$1 million ($710,000 US) grant to further the biotechnology company’s development of a new treatment for amyotrophic lateral sclerosis (ALS).

Specifically, the New York-based biotechnology company will use the funds to advance LAUR-301, a medicine that aims to reverse the progressive neurological disorder, rather than just postpone its progression. No such treatment currently exists.

Lauren Sciences specializes in medicines for neurodegenerative disorders using its V-Smart drug delivery platform. LAUR-301 is a V-Smart nanomedicine that targets brain areas affected by motor neuron death in ALS.

The pre-clinical therapy is crafted to cross the blood-brain barrier (BBB) by non-invasive administration, then to selectively deliver agents into brain areas affected by ALS degeneration, according to the company website.

It’s customized with therapeutic agent glial cell derived neurotrophic factor (GDNF), a neurotrophic protein that cannot cross the barrier by itself, which has been shown to protect motor neurons and help preserve the neuromuscular junctions — the contact point between a motor nerve cell and a muscle fiber. It has improved outcomes of ALS animal models.

Join our ALS forums: an online community especially for patients with Amyotrophic Lateral Sclerosis.

The grant project will study the therapeutic benefit of LAUR-301 in an ALS mouse model. The hope is that the U.S. Food and Drug Administration (FDA) ultimately will approve Lauren Sciences’ priority therapy.

”We commend FightMND for sharing our vision and commitment to LAUR-301,” Susan Rosenbaum, chairman and CEO of Lauren Sciences, said in a press release. “The FightMND award confirms LAUR-301’s success to date, ability to overcome the BBB [blood-brain barrier] delivery challenge, and value as a potentially life-saving therapeutic for all ALS patients.”

For its part, FightMND is excited about the potential treatment’s prospects.

”LAUR-301 has promise as an effective new treatment for ALS patients,” said Irwin Hollander, PhD, vice president of the organization’s research and development. “LAUR-301 will likely be a disease-modifying drug, unlike standard treatments that, in most patients, merely delay disease progression.”

ALS affects motor neurons in the brain and spinal cord, ultimately causing the loss of the ability to initiate and control muscle movement. According to the press release, more than 2,000 Australian residents live with ALS (also known as motor neuron disease). It also said that, based on population studies, some 5,600 U.S. residents are diagnosed with the disease annually.

The goal of FightMND is to find effective treatments and eventually a cure for the disease. The organization is the largest independent funding source of motor neuron disease in Australia.

Mary M. Chapman began her professional career at United Press International, running both print and broadcast desks. She then became a Michigan correspondent for what is now Bloomberg BNA, where she mainly covered the automotive industry plus legal, tax and regulatory issues. A member of the Automotive Press Association and one of a relatively small number of women on the car beat, Chapman has discussed the automotive industry multiple times of National Public Radio, and in 2014 was selected as an honorary judge at the prestigious Cobble Beach Concours d’Elegance. She has written for numerous national outlets including Time, People, Al-Jazeera America, Fortune, Daily Beast, MSN.com, Newsweek, The Detroit News and Detroit Free Press. The winner of the Society of Professional Journalists award for outstanding reporting, Chapman has had dozens of articles in The New York Times, including two on the coveted front page. She has completed a manuscript about centenarian car enthusiast Margaret Dunning, titled “Belle of the Concours.”
×
Mary M. Chapman began her professional career at United Press International, running both print and broadcast desks. She then became a Michigan correspondent for what is now Bloomberg BNA, where she mainly covered the automotive industry plus legal, tax and regulatory issues. A member of the Automotive Press Association and one of a relatively small number of women on the car beat, Chapman has discussed the automotive industry multiple times of National Public Radio, and in 2014 was selected as an honorary judge at the prestigious Cobble Beach Concours d’Elegance. She has written for numerous national outlets including Time, People, Al-Jazeera America, Fortune, Daily Beast, MSN.com, Newsweek, The Detroit News and Detroit Free Press. The winner of the Society of Professional Journalists award for outstanding reporting, Chapman has had dozens of articles in The New York Times, including two on the coveted front page. She has completed a manuscript about centenarian car enthusiast Margaret Dunning, titled “Belle of the Concours.”
Latest Posts
  • MND Association program
  • Clinical trial dashboard
  • ALS scholarships
  • ALS scholarships

How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?

Pin It on Pinterest

Share This