Boston-based Flex Pharma has announced positive topline results from its exploratory Phase 2 trial testing investigational therapy FLX-787 in Australian amyotrophic lateral sclerosis (ALS) patients with frequent muscle cramps. The data showed that FLX-787 significantly reduced the intensity of cramp-associated pain and stiffness compared to placebo. The positive results support the…
Findings from a Phase 3 study of tirasemtiv to improve muscle strength — particularly of respiratory muscles — in amyotrophic lateral sclerosis (ALS) patients will likely be announced for a first time on Dec. 8 at the 28th ALS/MND meeting in Boston, a vice president of Cytokinetics, its developer, said…
Being diagnosed with amyotrophic lateral sclerosis (ALS) is a difficult and stressful time. You’ll probably feel incredibly overwhelmed in the first few days and weeks, and struggle to understand the ramifications involved. To help with the process, we’ve compiled a list of tips for patients who have recently been diagnosed with…
Even though November is National Caregivers Month, I think we also should include Good Samaritans and caring strangers. Everyone who opens a door or helps carry a bag, hands us items off the top shelf or points us in the right direction; a big thank you…
Scientists have long linked abnormal versions of the protein TDP-43 to neurodegenerative diseases such as ALS, but they haven’t had a full understanding of how it causes nerve cell deterioration. A Japanese study in mice indicates that elevated levels of the normal version of TDP-43 can play a role in…
This ALS Association video is all about Nanci Ryder. Nanci is a much-loved Hollywood publicist who was diagnosed with amyotrophic lateral sclerosis (ALS) in 2014. MORE: Four ALS heroes the ALS Association honored for outstanding contributions The ALS Association’s Golden West Chapter has honored Nanci as one of their…
The Muscular Dystrophy Association (MDA) has awarded an MDA Venture Philanthropy (MVP) grant worth $233,200 to Iron Horse Diagnostics to support the development of a biomarker test for amyotrophic lateral sclerosis in the United States. The prognostic test, which was released in Europe in June under a license agreement…
Everyone suffers from stress from time to time but when you have a chronic disease, stress not only adds to your everyday burden but can often exacerbate the symptoms of your condition. While we can’t avoid stress altogether, there are ways that we help ourselves relax more and not let things…
Researchers at Germany’s University of Würzburg have discovered how a malfunctioning autophagy – a cell’s natural self-degradation and cleanup system – plays a central role in the development of amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. The study, “Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism…
Biohaven Pharmaceutical has dosed the first amyotrophic lateral sclerosis (ALS) patient with its sublingual formulation of riluzole, BHV-0223, in a pivotal Phase 2/3 trial. The trial aims to demonstrate that BHV-0223’s effects are at least equivalent to Rilutek, an approved tablet formulation of riluzole. The trial initiation was supported by…
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