Size of SOD1 Protein Aggregates in ALS Patients’ Brains Leads to Different Outcomes, Study Shows

Size matters when it comes to SOD1 protein aggregates found in the brains of patients with amyotrophic lateral sclerosis (ALS), according to researchers. They found that large SOD1 aggregates may help protect motor neurons from dying, while short SOD1 aggregates promote the death of motor nerve cells. Their findings support…

The ALS Association and Cytokinetics will continue to collaborate in the fight against amyotrophic lateral sclerosis (ALS) through a series of initiatives and research efforts, the organizations recently announced. As part of this partnership, biopharmaceutical company Cytokinetics is renewing its sponsorship of nationally recognized ALS Association events, including the National…

New technology that tests therapies designed for disorders of the neuromuscular junction, such as amyotrophic lateral sclerosis (ALS), closely mimics the human condition and offers a new method of drug testing, according to a report. The paper, “Stem cell derived phenotypic human neuromuscular junction model for…

Are you ready? Then let’s GO! We can climb a mountain, walk a mile, drink a beer, or just shop online — all to raise money for ALS. In the U.S., the month of May traditionally has been designated as ALS Awareness Month. In the U.K., where…

MediciNova’s investigational therapy MN-166 (ibudilast) was able to delay disease worsening and improve survival in amyotrophic lateral sclerosis (ALS) patients, updated data from a Phase 2 clinical trial show. The study, “Ibudilast — Phosphodiesterase Type 4 Inhibitor — Bi-Modal Therapy with Riluzole in Early [Not…

Investigational therapy NP001 failed to improve disease severity and pulmonary function in a Phase 2 confirmatory trial for amyotrophic lateral sclerosis (ALS) patients with elevated levels of systemic inflammation, Neuraltus Pharmaceuticals announced. The findings, showing the trial failed to meet its primary and secondary goals, were recently shared during the…

A new Japanese joint venture company called MAGiQ Therapeutics — the result of a collaboration between Q Therapeutics and Reprocell — aims to develop cell and gene therapies for demyelinating and degenerative diseases of the central nervous system. Among the first diseases its efforts will target is amyotrophic lateral sclerosis (ALS), a…

Anxiety and depression were found to be associated with caregiver burden in people caring for amyotrophic lateral sclerosis (ALS) patients, according to a study. Researchers found that anxiety was mainly observed in those with a low caregiver burden, and depression was seen more widely in those with a high…

In last week’s column, I shared how the simple strategy of showing up helps me live with ALS. This week, I have a suggestion for something that should be at the top of your list of things to show up for: your ALS support group. ALS support groups…

A diet that includes foods rich in omega-3 polyunsaturated fatty acids like alpha-linolenic acid — an essential plant-derived fatty acid found in flaxseed, canola, and other oils — is linked to a lower risk of developing amyotrophic lateral sclerosis (ALS), researchers report. But their work also found that diets rich in arachidonic…