Researchers Develop New Molecule, 123C4, with Possibility to Treat ALS

Researchers have developed a molecule called 123C4 that targets the EphA4 receptor, which is known to contribute to the development of amyotrophic lateral sclerosis (ALS), according to a new study. The paper, “Potent and Selective Epha4 Agonists for the Treatment of ALS,” appeared in the journal Cell Chemical Biology. Its…

Patients with chronic conditions like amyotrophic lateral sclerosis (ALS) are as concerned as the general population about health care costs, but see benefits in the Affordable Care Act (ACA) that the healthy may have overlooked, a poll indicates. These findings are reported in a new large-scale poll assessing patient…

Swiss drugmaker GeNeuro has signed an agreement with the National Institute of Neurological Disorders and Stroke (NINDS) — part of the U.S. National Institutes of Health (NIH) — to advance studies of its novel therapeutic antibodies for the treatment of amyotrophic lateral sclerosis (ALS). Under the Cooperative Research and Development Agreement, GeNeuro will…

Heavy metal pollution may not be as important as previously thought in the development of amyotrophic lateral sclerosis (ALS), according to new research by Italian scientists.

Natural substances that restore intestinal-bacteria balance may help in the treatment of   amyotrophic lateral sclerosis (ALS), according to a study funded by the international Ice Bucket Challenge. Noting that changes in intestinal bacteria contribute to ALS, researchers said using probiotics could restore the balance. The research, “Target Intestinal Microbiota…

Everyone suffers from stress from time to time but when you have a chronic disease, stress not only adds to your everyday burden but can often exacerbate the symptoms of your condition. While we can’t avoid stress altogether, there are ways that we help ourselves relax more and not let things…

In this TEDx Talks video, Steven Boeynaems explains that although we have known about amyotrophic lateral sclerosis (ALS) for 140 years, scientists still know very little about the condition that affects around 200,000 people worldwide. Discover seven interesting facts about ALS here. Boeynaems talks about the role of TDP-43 proteins…

This moving film from Brattleboro Reformer features Andy and his wife Kathleen. Andy has amyotrophy lateral sclerosis (ALS) and talks candidly about some of the simple things he misses in life. Read about five common misconceptions about ALS. Andy explains that ALS progresses differently in each patient,…

A Phase 2 clinical trial, exploring ozanezumab as a treatment of amyotrophic lateral sclerosis, failed to show any benefits. The data at hand means the search for treatments that may outperform the only approved ALS medication, riluzole, continues. The study, “Safety and efficacy of ozanezumab in patients with…

ALS patients with complete paralysis can communicate in a limited manner using a computer interface that detects their thoughts based on blood oxygen levels in the brain, according to a new study. Researchers said the method helped these patients say they were happy despite their extreme condition. The study, “Brain-Computer…