ALS-causative Mutations Directly Affect Sensory Nerves’ Growth and Stress Response, Preclinical Study Shows
Sensory nerves carrying mutations in the TDP-43 or SOD1 genes — associated with the development of a…
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Tiglutik (Riluzole Oral Suspension) for ALS
Last updated Jan. 16, 2023, by Teresa Carvalho, MS Fact-checked by Inês Martins, PhD What is Tiglutik for ALS? Tiglutik (riluzole oral suspension) is a liquid formulation of riluzole approved for treating amyotrophic lateral sclerosis (ALS). It can be taken orally or administered through a feeding tube…
Molecular Pathway Seen as ‘Intimate Tie’ Between ALS and Spinal Muscular Atrophy
Mutations that affect a particular molecular pathway essential to protein production further support reports of a link between amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). The study detailing this finding, “The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex,”…
Gene Therapy That Lowered SOD1 Protein in Primates Could Be Effective in ALS, Study Suggests
A gene therapy effectively and safely lowered the production of a key amyotrophic lateral sclerosis (ALS) protein called superoxide dismutase 1 (SOD1) in primates, according to a new study. “This level of silencing, coupled with the lack of adverse effects, suggests that this approach to treating ALS should be…
Spinal Fluid and Blood Proteins May Diagnose and Predict Outcomes in ALS, Study Finds
Specific proteins analyzed in cerebral spinal fluid and blood samples may help to diagnose amyotrophic lateral sclerosis (ALS) and predict patient outcomes, researchers report. Cerebral spinal fluid (CFS) protein patterns helped to identify 94% of ALS patients in their study, and the levels of three specific proteins were seen to…
ALS and Genetics
While genetics alone do not cause amyotrophic lateral sclerosis (ALS), a large number of genetic mutations have been associated with the neurodegenerative disease. Such mutations can increase a person’s risk of developing ALS, also known as Lou Gehrig’s disease, which affects motor neurons, the nerve cells that…
Prevalence of Motor Nerve Diseases, Including ALS, on Rise as Population Ages
The prevalence of motor nerve diseases — including amyotrophic lateral sclerosis (ALS) — is on the rise worldwide, mostly because of an aging population. The disease burden is greatest in high-income countries, according to a global analysis of data from 1990 to 2016. The study, “Global, regional,…
Teens and Young Adults Living with ALS Invited to Speak Out via Artist Creations in ‘Also Us’ Program
To bring attention to the plight of teens touched by amyotrophic lateral sclerosis (ALS), Mitsubishi Tanabe Pharma America (MTPA) is calling for artistic submissions from young people who have a family member with the disease. Called ALSO US, the new initiative is open to U.S. teenagers and young…
SARM1 Inhibition Has Potential to Prevent Neurodegeneration in ALS, Other Diseases, Preclinical Results Suggest
Inhibition of the SARM1 gene can prevent the degeneration of nerve cells in the central, ocular, and peripheral nervous system in mice, results from preclinical studies show. These findings provide evidence for the use of small-molecule inhibitors of the SARM1 protein being developed by Disarm Therapeutics as potential disease-modifying therapeutics for…
FUS Mutation Common to Familial ALS Impacts DNA Repair Pathways in Motor Neurons, Study Shows
Mutations in a gene linked to familial amyotrophic lateral sclerosis (ALS), called FUS, affect the ability of motor nerve cells to repair damage to their DNA, a new study shows. These findings suggest that therapies that enhance the repair of DNA damage may be of benefit to some ALS patients.