A new study is investigating the longer-term effects — over a one-year period — of the therapy candidate reldesemtiv in people with amyotrophic lateral sclerosis (ALS). Cytokinetics has launched an open-label extension (OLE) study to evaluate the safety and effectiveness of reldesemtiv over a longer course in patients…

Note: This story was updated June 16, 2022, to reflect that competitor Kyle Brown was not disqualified, but did not finish the swim portion of the Ironman World Championship within the time limit and was not able to move forward in the competition.   Patrick Harfield was on his last legs.

Radicava ORS, an oral formulation of edaravone recently approved to treat amyotrophic lateral sclerosis (ALS) in the U.S., was safe and generally well-tolerated over almost a year of treatment in a Phase 3 clinical trial, new data highlight. The results were presented by the therapy’s developer, Mitsubishi Tanabe…

AKAVA Therapeutics’ experimental therapy AKV9, formerly NU-9, was superior to approved therapies for amyotrophic lateral sclerosis (ALS) at improving the health of lab-grown upper motor neurons from a mouse model of the disease, a study shows. Upper motor neurons are one of the two types of specialized nerve cells that…

As I left our house to get the kids from school, the tree was gone. A contractor’s crew was removing brush from the ditch with an excavator to extend the culvert that passed under our driveway. My husband, Todd, had specifically asked that the poplar tree be left alone. I…

Dutch Bros Coffee has long supported efforts from the Muscular Dystrophy Association (MDA) to help patients with amyotrophic lateral sclerosis (ALS) and other neuromuscular diseases and to fund research. It recently outdid itself, though, raising $2.3 million for the organization in a single day. Proceeds from Dutch…

Note: This story was updated June 7, 2022, to note that CENTAUR is a Phase 2, not Phase 2/3, trial and that AMX0035 reduced the risk of death by 43%, instead of 44%. There also has been no indication that U.S. sites will open soon for the PHOENIX trial.

Every Memorial Day, I go with my mom, daughter, and son to the Lakeside Cemetery in Hancock, Michigan, to attend a ceremony honoring veterans. I drive separately in case I need to return home quickly to help my husband, Todd, who has ALS. The ceremony ends with the…

Major league baseball teams are poised to mark Lou Gehrig Day, set aside to honor the legendary New York Yankees first baseman whose career was cut short amyotrophic lateral sclerosis (ALS), the progressive neurodegenerative disorder that after his death in 1941 became known as “Lou Gehrig’s Disease.” In addition to…

“What’s the buzz? Tell me what’s a-happening, Why should you want to know? Don’t you mind about the future? Don’t you try to think ahead? Save tomorrow for tomorrow, Think about today instead.” — Andrew Lloyd Webber and Tim Rice, “What’s the Buzz,” from the rock opera “Jesus Christ…