An experimental oral therapy for amyotrophic lateral sclerosis (ALS) that’s being developed by Athira Pharma was shown to be safe and well tolerated in healthy volunteers who took part in a Phase 1 clinical trial, and the treatment entered the participants’ brain and spinal cords at dose-proportional levels.

Genetically reprogramming nerve cells to reverse aging may be a viable strategy for treating amyotrophic lateral sclerosis (ALS), a mouse study showed. Researchers found that a gene therapy made the mice’s nerve cells younger and more resilient, which delayed the onset of ALS symptoms. “Our hope is that this…

Having ALS is certainly no laughing matter. But I’ve found over the years that it can give rise to many humorous moments. On some days, in fact, finding the funny while in a frustrating situation has been one of my best coping strategies. That’s why I was taken aback to…

I was recently asked, “What can I do to support someone diagnosed with ALS?” I thought back to the days after my husband, Todd, was diagnosed with the disease. We knew little about it, except that it resulted in paralysis and usually death within two to five years.

Researchers at Yale School of Medicine said they’ve solved a longstanding mystery of how mutations in the C9ORF72 gene, a common genetic cause of amyotrophic lateral sclerosis (ALS), may lead to toxic proteins. The findings suggest a new approach that could lead to the development of targeted therapies, the researchers…

Long-term exposure to sulfur dioxide (SO2), a gaseous air pollutant generated by the burning of fossil fuels, significantly increases the risk of developing amyotrophic lateral sclerosis (ALS), according to a study in Canada. Exposure to other forms of air pollution, including nitrogen dioxide (NO2), ground-level ozone (O3), and PM2.5…

A wearable robot that detects small arm motions and helps support the shoulder can make it easier for amyotrophic lateral sclerosis (ALS) patients to pick up and carry things, a study showed. ALS is a neurological disorder that causes progressive muscle weakness and eventual paralysis. Weak limbs make many…

Measuring the electrical activity of muscles in the neck can help clinicians to identify dysfunction in certain motor neurons — the nerve cells that control voluntary movement — in people with amyotrophic lateral sclerosis (ALS), a study from researchers in China demonstrates. Similar testing is now often done using…

Immune cells in the brain exhibit distinct profiles in the brain and spinal cord of people with amyotrophic lateral sclerosis (ALS), a study finds. A better understanding of the cells, called microglia, which are long believed to contribute to inflammation and damage in ALS, could help scientists come up…