Showing 2680 results for "amyotrophic lateral sclerosis (ALS)"

Human Skin Cells Successfully Converted into Motor Neurons

Scientists have discovered how adult skin cells can be converted into motor neurons without transitioning them through a stem cell state. The findings promise to help researchers better understand motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). The study, “MicroRNAs Induce a Permissive Chromatin Environment that…

Amylyx, Project ALS Collaborate on Preclinical Study to Test AMX0035 as Potential ALS Therapy

Project ALS and Amylyx Pharmaceuticals will collaborate on preclinical studies of Amylyx’s lead compound AMX0035 as a potential treatment for patients with amyotrophic lateral sclerosis (ALS). These studies will complement Amylyx’s recently initiated Phase 2 CENTAUR clinical trial (NCT03127514), which will evaluate AMX0035 in 132 patients. Since mitochondrial…

A Song Inspired by ALS: ‘The Last Poem’

This video from Alisa Apreleva is all about an awareness campaign in Moscow, Russia, that’s helping to highlight amyotrophic lateral sclerosis (ALS). MORE: What research is being done on ALS? The video features Russian recording artists and patients in various stages of the disease singing a specially written and composed…

An ALS Documentary: ‘Mr Connolly Has ALS’

https://vimeo.com/216244227 This film by Dan Habib is all about the extraordinary life of high school principal Gene Connolly. Connolly was the much-loved principal of Concord High School for 14 years before he was struck by amyotrophic lateral sclerosis (ALS) in 2014. MORE: Explaining the progression…

Dutch Study Reveals New Genes and Disease Mechanisms Associated with ALS

Dutch researchers have identified new genes and biological mechanisms possibly involved in frontotemporal dementia (FTD) with and without amyotrophic lateral sclerosis (ALS). The study, “Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS,” appeared in the…

Researchers Identify Novel Genes that Regulate Muscle Stimulation and Regeneration in ALS

Levels of some microRNAs (MIRs) regulating re-innervation and muscle regeneration among amyotrophic lateral sclerosis (ALS) patients, while others are lower, an Italian study has found. These molecules help distinguish slow from rapid-progression ALS, and the findings suggest that therapeutic approaches targeting these MIRs may help delay disease progression. The study,…