Polygenic scoring system may help to predict ALS risk
A new genetic risk score that takes hundreds of different genetic variations into account may help predict who’s most likely…
Articles by Marisa Wexler, MS
ALS research into miR-155 blockers advances to animal testing stage
Work into developing molecules that block microRNA-155 (miR-155) as potential treatments for amyotrophic lateral sclerosis (ALS) has advanced to…
Specific mRNA molecule may be useful as biomarker in ALS
A messenger RNA (mRNA) molecule that provides the instructions for a protein involved in glutamate signaling is not edited as…
Gout medication decreases risk of ALS and other diseases: Study
Allopurinol and carvedilol, two medications respectively used to manage gout and high blood pressure, significantly reduce the chances of developing…
Some sporadic ALS patients have mutation causing other diseases
A sizable portion of people with sporadic amyotrophic lateral sclerosis (ALS) carry a genetic mutation known to cause other…
Early clinical trial testing gut microbe transplants in ALS patients
An early clinical trial is testing whether fecal microbiota transplants (FMT) — a procedure that aims to introduce healthy bacteria…
AAN 2023: Radicava leads to better long-term survival in ALS
Radicava (edaravone) significantly prolongs long-term survival for people with amyotrophic lateral sclerosis (ALS), according to an analysis of…
AAN 2023: ALS treatments ID’d in HEALEY head toward Phase 3 tests
It’s been nearly three years since the HEALEY platform clinical trial started and, so far, two promising experimental treatments for…
AAN 2023: DNL343 is safe, appears to work as intended in Phase 1 trial
Treatment with the investigational therapy DNL343 was generally well-tolerated among people with amyotrophic lateral sclerosis (ALS) in an early…
Colder temperatures help cells to clear toxic proteins tied to ALS
Cold temperatures can activate a complex called the proteasome that cells use to clear themselves of unneeded proteins, including the…