Altered, Toxic SOD1 Protein ‘Shared Feature’ Across ALS Types
Altered forms of the SOD1 protein are found in the spinal cord nerve cells of people with all types of…
Articles by Marisa Wexler, MS
Gene Therapy SynCav1 Found to Extend Survival in ALS Mouse Model
Treatment with gene therapy candidate SynCav1 delayed disease onset and extended survival in a mouse model of amyotrophic lateral sclerosis (ALS),…
Approved Medication Terazosin May Be ‘Exciting’ New ALS Treatment
Treatment with terazosin, a medication approved to treat high blood pressure and enlarged prostate, was found to protect motor neurons…
ALS Link With Specific STMN2 Gene Mutation Challenged in Study
A mutation in the STMN2 gene that consists of an excessive repeat of two nucleotides, the building blocks of DNA, is not…
Loss of STMN2 Protein Contributes to ALS Progression, Study Finds
TDP-43 protein abnormalities characteristic of most amyotrophic lateral sclerosis (ALS) cases contribute to the loss of motor neurons mostly…
FDA Reviewing Tofersen for SOD1-ALS; Decision Expected in January
The U.S. Food and Drug Administration (FDA) has agreed to review an application from Biogen for approval of the…
Experimental Antibody GNK301 Shows Promise in Treating ALS
A viral protein called HERV-K ENV is often detectable in the fluid around the brains of people with amyotrophic…
Inflammatory Immune Cells May Be Biomarker for Juvenile Type of ALS
Amyotrophic lateral sclerosis (ALS) type 4 — a juvenile and slowly progressive form of the neurological disease, called ALS4…
Imaging Analysis Platform May Help Diagnose ALS
An imaging analysis platform that examines the brain’s white matter in MRI scans could help to diagnose amyotrophic lateral…
Radicava’s Real-world Safety Profile Matches Clinical Trial Data: Study
Using the approved treatment Radicava (edaravone) in a real-world setting resulted in a similar safety profile as that reported…