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How does neuronal activity trigger an increase in the supply of blood?
No one knows the etiology of ALS. Some scientists believe that the blood supply may be an important factor. This is an interesting hypothesis because it would group many neurodegenerative diseases under a common umbrella. Depending on the area of the brain that would be affected, this would cause ALS (motor cortex) or Parkinson’s (midbrain), etc.
While not specifically mentioning neurodegenerative diseases, two papers, by Chow et al and Grubb et. al, significantly advance our understanding of neurovascular physiology and blood flow control.
These two papers are milestones from the point of view of science on the brain’s vascular component.
* Chow BW, Nuñez V, Kaplan L, Granger AJ, Bistrong K, Zucker HL, Kumar P, Sabatini BL, Gu C. Caveolae in CNS arterioles mediate neurovascular coupling. Nature. 2020 Feb 19;
* Grubb S, Cai C, Hald BO, Khennouf L, Murmu RP, Jensen AG, Fordsmann J, Zambach S, Lauritzen M. Precapillary sphincters maintain perfusion in the cerebral cortex. Nat Commun. 2020 Jan 20;11(1):395.
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