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    • #17928
      Richard
      Participant

      Hi All,

      Preclinical research has shown that the administration of ketamine preserves muscle function in advancing ALS and increases life expectancy when given in the early stages of muscle decline.

      https://apnews.com/press-release/globe-newswire/business-government-business-and-finance-products-and-services-government-regulations-drug-approvals-10b8a053c699f84c2e54ca22c960ea60

      Another preclincial research success story. Will further clinical trials, be timely and backup the original claims or is this just more dashed hopes?

       

      Richard

       

    • #17934
      Christine Moretti
      Participant

      Hi Richard, I was intrigued when I read your post. One, I think it further illustrates how vital biomarkers are in ALS as it seems most trials stress the importance of early intervention, although this study does indicate late stage use as you said.

      The other thing that struck me was the drug itself.  I am wondering what type of side effects, sedation, hallucinations, etc.  patients would experience. After looking it up online, ketamine sure sounds like an intense drug.

      Always with an open mind, I hope for success for this drug. I am all for research of any kind and orphan drugs are a good target.

      Thanks for sharing.

       

       

       

    • #17941
      Chuck Kroeger
      Participant

      Ketamine, PrimeC, NU9,  nurown… So many things come out that sound promising that turn out to be less than effective.  Its hard to get excited when you read about the newest wonder drug.  Can only hope and pray that one of them  will actually work the  way the initial experiments say it can

    • #17975
      Jim
      Participant

      Yes, Ketamine is a very serious drug. It’s very clean feeling, very, very hallucinogenic and can have out of body experiences! Some of these trials are ridiculous, like the researchers are just trying any substance. Hope these trials don’t cost too much money! Doesn’t seem like ketamine would slow any ALS progression, But Not sure how Ketamine works on a cellular level with Neurons. There for sure would be lots of freaking out!

    • #17991
      Cindy Puskar
      Participant

      I was given ketamine once during an MRI and it was one of the worst experiences of my life.  Horrible hallucinations.

    • #20196
      Jim Conner
      Participant

      Lordy when I read Ketamine for ALS my spine shivered. I used Ketamine with Rompin (sic) to tranquilize bears. We tried it on elk and moose and probably killed the critters the day after we released them due to spiking blood pressure. Keep that crap as far away from me as possible. Yuck.

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