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    • #19460
      Richard
      Participant

      Hi All,

       

      Researchers now report a high-throughput target and drug discovery platform using motor neurons made from ALS patients. Using the platform, they confirmed two known targets and identified an existing class of drugs — agonists to the dopamine D2 receptor — as potential novel treatment.

       

      https://www.sciencedaily.com/releases/2021/06/210608113241.htm

       

      Richard

       

    • #19470

      Recently it was announced that Ropinorole, a Parkinson drug, had some effects in ALS, but there was no accompanying scientific report.

      Parkinson’s disease, is caused by a loss of dopamine-secreting neurons in an area of the midbrain called the substantia nigra. Yet it would be a bit strange if there was a common causal mechanism between Parkinson and ALS.

    • #19471
      Duane
      Participant

      Some of these may exhibit a “side or secondary effect” as well as a main effect.

      Regarding this topic, here is a excellent article concerning what is happening at Mayo now:

      https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/focus-areas/neuroregeneration

       

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