Showing 4140 results for "als"

Diarrhea a barrier to using common ALS medication: Surveys

Note: This story was updated Aug. 22, 2023, to correct there are four ALS approved therapies widely available in the U.S. Diarrhea associated with a common amyotrophic lateral sclerosis (ALS) treatment could be a substantial barrier to complying with the medication, according to surveys by Napo Pharmaceuticals. While…

Regulatory T-cells (Tregs) – ALS News Today

Regulatory T-cells (Tregs) are a type of white blood cell that functions to suppress the body’s immune response and prevent unnecessary inflammation. Tregs are part of the immune system, and can also enter the brain and the spinal cord to reduce neuroinflammation. In amyotrophic lateral sclerosis (ALS) ­— a…

ALS survival benefits with Radicava to be studied as part of collaboration

Mitsubishi Tanabe Pharma Canada (MTP-CA) is teaming up with the Canadian Neuromuscular Disease Registry (CNDR) in Canada’s first real-world, evidence-generating study of Radicava (edaravone) in amyotrophic lateral sclerosis (ALS). Data are expected to provide real-life insights into the survival benefits of Radicava in the progressive neurodegenerative…

Survival in sporadic ALS linked to autophagy protein p62

Increased accumulation of p62, a protein involved in a cellular recycling process called autophagy, in the spinal cord is associated with worse survival outcomes in people with sporadic amyotrophic lateral sclerosis (ALS), a study revealed. Autophagy is the cellular process responsible for breaking down proteins and other complex molecules…

Genetic factors influencing ALS survival identified in Japanese study

Researchers have identified new genetic variants that might influence survival among sporadic amyotrophic lateral sclerosis (ALS) patients in Japan. Genetic analyses in more than 1,000 ALS patients uncovered that small changes in the FGF1, THSD7A, and LRP1 genes could affect patients’ prognosis. In patient-derived nerve cells, the identified variants led…