Search Results for: superoxide dismutase 1

June 4, 2019June 4, 2019

SOD1 Enzyme Clumps May Expose Cells to DNA Damage in Some ALS Patients, Study Suggests

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The enzyme superoxide dismutase 1 (SOD1) forms clumps inside the cells of some people with sporadic amyotrophic lateral sclerosis (ALS), making them more vulnerable to DNA damage — which ... Read more

May 13, 2019May 13, 2019

Investigational ALS Treatment NPT520-34 Begins Phase 1 Trial in Healthy Volunteers

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NPT520-34, an investigational small molecule for the treatment of Parkinson’s disease and amyotrophic lateral sclerosis (ALS), is being tested on healthy individuals in a new Phase 1 clinical trial, its developer ... Read more

January 14, 2019January 14, 2019

Human-derived Antibody Against SOD1 Aggregates Improves ALS Symptoms in Mouse Model, Study Shows

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A human-derived antibody that specifically binds to abnormal superoxide dismutase 1 (SOD1) improved the symptoms and delayed disease progression in a mouse model for amyotrophic lateral sclerosis (ALS), a study ... Read more

November 30, 2018November 30, 2018

Gene Therapy Holds Promise to Treat ALS Caused by SOD1 Mutations, Preclinical Study Shows

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An experimental gene therapy based on RNA interference (RNAi) shows potential to treat patients with familial amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) ... Read more

November 14, 2018

Gene Therapy That Lowered SOD1 Protein in Primates Could Be Effective in ALS, Study Suggests

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A gene therapy effectively and safely lowered the production of a key amyotrophic lateral sclerosis (ALS) protein called superoxide dismutase 1 (SOD1) in primates, according to a new study. ... Read more

October 18, 2018October 18, 2018

Voyager Therapeutics Announces Promising Animal Study Data of VY-SOD102 for ALS

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Voyager Therapeutics’ experimental therapy VY-SOD102 shows promise for treating patients with familial amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene, according to results ... Read more

September 24, 2018September 24, 2018

Misfolded SOD1 Protein May Have Key Role in Sporadic ALS, Study Suggests

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Specific patterns of a misfolded protein — superoxide dismutase 1 (SOD1) — are found in the brain and spinal cord of patients with sporadic amyotrophic lateral sclerosis (ALS), according to ... Read more

May 23, 2018May 23, 2018

Voyager Shares Promising Pre-clinical Data About ALS Therapy Candidate VY-SOD101

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Voyager Therapeutics presented new data from a study in an animal model of its clinical candidate VY-SOD101, showing the therapy is effective as it targets the most common cause ... Read more

Tofersen (BIIB067 – Previously IONIS-SOD1Rx)

Tofersen (BIIB067) previously called IONIS-SOD1Rx is an investigational therapy to slow the progression of familial amyotrophic lateral sclerosis (ALS). The therapy was developed in a collaboration between Ionis Pharmaceuticals ... Read more

February 15, 2017February 15, 2017

Interview with Prize4Life and French Team That Won $1M Award for ‘Effective’ ALS Gene Therapy Approach

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Two French researchers, Martine Barkats and Maria-Grazia Biferi, are winners of the Avi Kremer ALS Treatment Prize, worth $1 million, for developing a gene therapy approach that shows promise in ... Read more

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