Author Archives: Alice Melão

Patients Seek Therapies That Might Stop Progression and Ease Burden of ALS, Online Survey Finds

The majority of patients with amyotrophic lateral sclerosis (ALS) report wanting new treatments to stop their disease’s progression and so improve breathing function, muscle strength, and mobility, according to the results from a self-reported online survey of ALS patients and caregivers. These findings may help define future guidelines for the development…

SARM1 Inhibition Has Potential to Prevent Neurodegeneration in ALS, Other Diseases, Preclinical Results Suggest

Inhibition of the SARM1 gene can prevent the degeneration of nerve cells in the central, ocular, and peripheral nervous system in mice, results from preclinical studies show. These findings provide evidence for the use of small-molecule inhibitors of the SARM1 protein being developed by Disarm Therapeutics as potential disease-modifying therapeutics for…