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Berberine and TDP-43
Hi All,
First time post in this forum – please let me know if I am posting in the wrong section.
So my query is a two part questions.
I’ve been coming across a lot of research involving TDP-43 and MND. I was wondering if the research is showing that the misfolded protein is a cause of some/all of the damage occuring in MND or if is it more a symptom?
The second part to that is I came across the following paper: https://www.mdpi.com/1422-0067/21/10/3443/htm ‘Enhanced Clearance of Neurotoxic Misfolded Proteins by the Natural Compound Berberine and Its Derivatives’ which references TDP-43 and I found another paper that confirms that Berberine crosses the blood brain barrier.
The thing that confuses me is I see papers talking about berberine being neurotoxic and potentially having neurodegenerative effects:
- ‘Mitochondria and NMDA Receptor-Dependent Toxicity of Berberine Sensitizes Neurons to Glutamate and Rotenone Injury’ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156429/
- ‘Neurotoxic effects of berberine on long-term L-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson’s disease’ https://pubmed.ncbi.nlm.nih.gov/23539311/
and other papers pointing to a benefit:
- Berberine and neurodegeneration: A review of literature https://www.researchgate.net/publication/277592426_Berberine_and_neurodegeneration_A_review_of_literature
So in summary – does clearing misfolded TDP-43 slow down the progression of MND? Has anyone looked into berberine – is there a reason it’s not being pursued for clinical trials or is it a resource/money thing? Can anyone comment on the contrasting views on it’s neurotoxicity?
Your help is much appreciated!
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