Dogs Who Received Riluzole Two Ways Fared Well in ALS Study

In a study using dogs, the combination of infusing riluzole directly into the spinal cord and also taking it orally increased the concentration of the medication in the spinal cord significantly, compared to oral administration alone. The results of the study suggest that this combination therapy may increase its benefits…

Assessing the degree of atrophy, or shinkage, in facial nerves with a high-resolution imaging tool appears to provide an accurate and early diagnosis of amyotrophic lateral sclerosis (ALS), according to new research. The study, “Facial nerve atrophy in patients with amyotrophic lateral sclerosis: Evaluation with fast…

Inhibition of a protein called Cdk5 in the brain increases lifespan and improves motor function in mice with amyotrophic lateral sclerosis (ALS), a new study reports. This evidence supports a potential role for Cdk5 in the progression of ALS and opens new avenues as a potential therapeutic target for…

My name is Michael Morale. As director of multichannel content for Bionews Services, my job is to bring engaging multimedia content to all of our rare disease communities. I would like to introduce some of the resources available to our ALS News Today forum members, as well…

A new molecular mechanism that contributes to the death of some nerve cells has been discovered by a team of scientists led by researchers at Oregon State University. The researchers found that blocking a protein called HSP90 can result in the activation of a receptor present in motor…

After we got married, Todd and I bought an adorable, craftsman-style bungalow in a Milwaukee neighborhood. I believed living in the city would give me a better understanding of the issues faced by the families I served at an inner-city ministry, where I coordinated a tutoring program. Our next-door…

Mutations in the FUS gene, one of the most common causes of familial amyotrophic lateral sclerosis (ALS), increase the number of branches extending from the axons of motor nerve cells, so that no clear path exists for these neuronal “arms” to transmit information — in the form of electrical impulses —…

During my early childhood, I often played Chutes and Ladders. For those who are unfamiliar with the board game or have a foggy memory, the board is made up of 100 numbered squares. Beginning in the lower-left corner, players move a certain number of spaces, determined by…

People with amyotrophic lateral sclerosis (ALS) have higher blood serum levels of neurofilament light chain (sNfL) than do healthy people, a new study found. Its work also further supported sNfL’s usefulness as a marker of likely disease progression and outcomes, with higher concentrations indicating poorer survival. The research, “…

What does smiling have to do with ALS? Or happiness, contentment, or feeling positive? These expressions of our sense of well-being are important to those of us living with ALS. According to a study of 224 ALS patients, participants who had good emotional well-being experienced a slower progression…