High levels of 25-hydroxycholesterol, a cholesterol-related molecule, may trigger neuronal death and accelerate amyotrophic lateral sclerosis (ALS) progression, according to a new study. The finding could lead to new ALS therapies that target the molecule. The study, “25-Hydroxycholesterol Is Involved In The Pathogenesis Of Amyotrophic Lateral Sclerosis,” was published in the…
Cholesterol-Related Molecule May Be Linked to ALS Progression
Low levels of vitamin D, found in the majority of patients with amyotrophic lateral sclerosis (ALS), are linked to more extensive loss of movement, but do not predict the course of disease over a year. Instead, researchers found that taking vitamin D supplements was associated with a faster decline. The study’s…
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ALS Stories: Pam Kofstad
This video from ALSA Oregon is all about Pam Kofstad and her family. Pam’s health was on the decline for more than a year, starting with the inability to turn her left foot out and often tripping, which led to her being confined to a wheelchair. In April 2015, Pam was diagnosed with amyotrophic…
The Duke University ALS Clinic and the Freelon Foundation have announced a partnership to expand the school’s research on amyotrophic lateral sclerosis (ALS). The partnership will involve establishing an endowed professorship, providing funding for clinical trials, and increasing the number of patients the clinic can treat. Phil Freelon, who founded the Freelon Foundation…
Genervon Biopharmaceuticals has published a list of 89 genes associated with amyotrophic lateral sclerosis (ALS) that are modulated by its drug candidate GM6. The identification of the genes regulated by GM6 helps to explain the mechanism of action of this treatment, which aims to improve neuronal repair and survival, and…
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7 Interesting Facts About ALS
Amyotrophic lateral sclerosis (ALS) is sometimes known as Lou Gehrig disease after the baseball player who famously suffered from the disease. We’ve listed seven facts about ALS you should know about with help from prevention.com and the ALS Therapy Development Institute. The first symptoms of ALS usually appear…
A new program at the University of Pennsylvania will pursue ways to use gene therapy and genome editing to treat amyotrophic lateral sclerosis (ALS). The Program of Excellence for Motor Neuron Disease, launched by researchers at the Orphan Disease Center (ODC) in the university’s Perelman School of Medicine, will receive…
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ALS Stories: Christi Wyatt Zimmerman
In this video from Tyler Morning Telegraph shared in September 2015, we meet the amazing Christi Wyatt Zimmerman. Soccer coach mom talks about her life with ALS. Christi from Texas was diagnosed with amyotrophic lateral sclerosis (ALS) in 2014 at just 36 years old. However, despite the…
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Belgium ALS Liga Take on the Mannequin Challenge
Have you taken part in the latest trend to go viral on the internet? Following the success of the Plank and ALS’s own Ice Bucket Challenge, the latest craze is to gather your friends for the Mannequin Challenge. The Mannequin Challenge requires of a group of people to stand completely still in…
Measures of respiratory muscle strength among patients with amyotrophic lateral sclerosis (ALS) can predict survival, both with and without the need for mechanical ventilation. Studies in which solid objective measures of disease prognosis are still scarce. But, serving as markers of prognosis, these measurements may aid in the development of…
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