A fast way to win ALS not totally but … (part 2)
One more week of my researches left.
I think it is a good idea to create two side therapy:
1st side – reduce incoming PrPC flow
2nd side – clear TDP-43 aggregates in nerve cells
1st side description
PrPC to PrPSc transformation looks like Henry Ford plant.
I think it is not possible to destroy it fast.
The best idea is to reduce incoming flow of PrPC and it can be done by proteasome.
From inhibitor for USP14 paper:
“The availability of IU1 has led to the identification of a growing number of proteins identified as apparent targets of USP14’s deubiquitinating activity. Proteins such as the androgen receptor, cyclic GMP-AMP synthase, vimentin, GFPu, CD3δ, and most notably the prion protein PrpC show accelerated degradation or reduced levels upon IU1 treatment, most simply accounted for by reduced deubiquitination at the proteasome”
It means that it is a good idea to test inhibitor for USP-14 on ALS mice and C9orf72 cases.
The good news – I know where it is possible to do and I think it will take not more than 2 months.
The bad news – I don’t have money to do this. We have to ask to dedicate full time team for this task and I think it will approximately cost 1 to 2 millions USD. It is my own opinion, I didn’t ask anybody about price.
We have to find companies which research inhibitor for USP14, if the result of previous task is good. I couldn’t find their names, but I know they are.
USP14 is usually linked to different cancer types. We should convince them to use inhibitor for ALS and start 1st clinical trial. Of cause we should find money or sponsor for this trial.
I don’t have any ideas how much it can be cost. ☹
2nd side description
I believe to ProMIS Neurosciences intrabodies.
The good news – they found and checked them (press release)
The bad news – it will take long time till human tests. A small company, not one product and they received COVID grant from government.
I think it is possible to speed up process, but it is a resource question. Money once again.
They have preclinical phase experience (https://promisneurosciences.com/product-portfolio/) for AD, to pass it the second time will be faster.
We have ideas and steps. The main question is money.
We can find them:
a) Crowdfunding (record youtube movies by us, share it by ourselves and popular people and etc) (difficult)
b) Grants (difficult and not quickly)
c) VC funds (difficult and not quickly)
What do you think?
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