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Using immunosuppressant drugs to halt / slow down ALS progression
Hi All
Hope you all feeling great today!
I have been reading a lot about causes / possible mechanisms / possible treatments for ALS. Among other possible causes (inflammation / toxicity / genetic / gut microbiome / protein folding / mitochondrial etc ) one of the possible one is response of immune system to the antibodies, T cells, chemokines and cytokines and other markers of inflammation, and related to systemic immune activation. Reduced regulatory T cells (Treg) correlate with the rate of disease progression (and there is already a clinical trial related to Treg therapy). Normal immune response is helpful but in case of this disease it is harmful and it continues to degenerate neurons.
Here is my thought: is there any chance of using immunosuppressant drugs which would shut down the immune system and hence immune response so as to prevent degeneration of neurons? has anyone done any experiment? can such a drug be used under some doctor’s observation?
Appreciate your thoughts,
Thanks
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