Masitinib met its main Phase 2 and 3 clinical trial goal of improving the functioning of amyotrophic lateral sclerosis (ALS) patients, according to its maker, AB Science SA. The randomized, double-blind AB10015 (NCT02588677) trial compared the effectiveness and safety of a combination of masitinib and riluzole with a combination of…
Researchers have identified molecular mechanisms that lead to the abnormal and toxic accumulation of proteins within neurons, according to a new study. For amyotrophic lateral sclerosis (ALS) patients, these findings may pave the way for the design of new therapies by targeting protein aggregation in the brain. The study, titled “Phase…
Healthcare workers who come into the home of terminally ill patients have an important role to play in the final weeks of a person’s life. In this video from Brattleboro Reformer, learn about some of the healthcare workers and volunteers who looked after ALS patient Andy during his final…
Amyotrophic lateral sclerosis (ALS) may be linked to genetic factors that promote cardiovascular fitness, according to a study indicating that ALS patients’ parents died of cardiovascular disease less often. But researchers underscored that it is not physical activity that increases the risk of ALS. The study, “Exploring…
A recent review highlights the importance of population-based registers of amyotrophic lateral sclerosis (ALS) in Europe, which for more than 20 years have helped scientists understand the disease’s incidence, prevalence, characterization and genetics, as well as the outcome assessment of clinical trials. The review, “The changing picture of amyotrophic lateral sclerosis: lessons from…
The creator of popular children’s animation series SpongeBob SquarePants, Stephen Hillenburg, has been diagnosed with amyotrophic lateral sclerosis (ALS) according to a report on variety.com. RELATED: Neurologist explains diagnosing ALS The 55-year-old announced that he was recently diagnosed with ALSÂ and is in the early stages of the condition.
What’s your nighttime routine like? In this humorous video from Gifted Lift, Lauren gives us a sneak peek into her nighttime routine as a person with a chronic illness. Discover seven facts about ALS you might find interesting. Having a healthy snack, enjoying life to the fullest, checking in with friends, as well…
Orangetheory Fitness and its franchises raised more than $2 million in two weeks for Augie’s Quest, a foundation dedicated to amyotrophic lateral sclerosis (ALS) research. Thanks to the support of its franchise owners, coaches, studio staff and more than 430,000 members across the U.S., Orangetheory Fitness was able to more…
Psychological factors and subjective experiences play a central role in the burdens felt by people who care for patients with amyotrophic lateral sclerosis (ALS), a new study says. The study, titled “Caregivers of Patients With Amyotrophic Lateral Sclerosis: Investigating Quality of Life, Caregiver Burden, Service Engagement and Patient Survival,“ appeared in the…
Researchers have mapped the possible changes in shape of a key amyotrophic lateral sclerosis (ALS) protein that becomes mutated, a development that could lead to understanding how the mutations contribute to the disease’s progression. The knowledge could also lead to new therapeutic agents to target the mutations. The protein, angiogenin, is present…
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