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    • #18960
      Jim
      Participant

      Hi Everyone, It may or may not be new knowledge, but have a theory about theo Possible or probable causes of ALS. Why are most of the large ALS clusters in the USA in the north near the Great Lakes and in the North East? Well, I have a theory or there is a theory?

      Looked at maps of ALS distribution, these clusters are near water, I then looked into algea/bacteria growth where these large ALS clusters are, both very similar, the distribution of bacteria/algea blooms and ALS populations. That’s probably not new knowledge (Below article), but that’s not particularly the theory.

      Looked into it further, mapped out all the nuclear/coal power stations distributions (maps) in the USA, Most the power stations are near or around the Great Lakes and in the North East/New England of USA. The distribution of power stations and ALS are almost identical or should I say very similar, is this ironic? What do you think?

      Did the same mapping, Globally and ALS follows the same distribution pattern with power stations. lots of power stations and ALS cases in the middle of Europe, not so much in S. America, or Asia, but that is changing with Asian, development. Many people know power stations nuclear/coal usually change thermal properties of water, change temperatures by heating/cooling water supplies, this can cause Cyanobacteria and Phycocyanin blooms. So, maybe, just maybe ALS is either caused by bacteria/algea blooms, maybe blooms from power station run off or electricmagnetic fields associated with power stations! Anyway, you can look at maps on your own, google it! What do you think? Interesting or just another theory? If this is old knowledge or already very well known, I apologize, but it’s still interesting! If we can find causes of ALS, easier to find a cure! All the Best! Jim

      Found article which discusses some of the above!

      “Mapping amyotrophic lateral sclerosis lake risk factors across northern New England | International Journal of Health Geographics | Full Text” https://ij-healthgeographics.biomedcentral.com/articles/10.1186/1476-072X-13-1

    • #19083
      Jim
      Participant

       

      Parkinson’s disease drug for ALS, Dopamine Agonist. Looks again promising! or another false claim.. Ropinirole/Requip

      “Parkinson’s disease drug proves effective against ALS in Japan research using iPS cells – The Mainichi” https://mainichi.jp/english/articles/20210521/p2a/00m/0sc/046000c

    • #19088
      Jim
      Participant

      May have to ‘Plea The Filth Amendment” right to remain silent rather than incriminate oneself! with that one Theory, but just passing on other people’s research/theories!

    • #19089

      Let me add one of my many dubious theories 🙂
      Scientists tell ALS is a motor neuron disease, but what we can see is muscle weakness and waste.
      So let forget the motor neuron thing and concentrate on what is visible.
      There is another disease, not well understood as well, which is named cachexia.

      There is no clear cause of cachexia, if you look at the section about mechanism in Wikipedia you will recognize many names, including oxidative stress, which happens when SOD1 is not functional, anomalies in ubiquitin–proteasome system (UPS) or Nf-Kb that JP Julien thinks it is one of the main causes in ALS.

      TDP-43 aggregates in cytosol which happen in more than 95% of pALS, has many biological roles, one is about regulating body fat composition and glucose homeostasis in vivo.

      Neurons cells are close cousins to muscle cells…

      • #19436
        john s
        Participant

        “Neurons cells are close cousins to muscle cells…”

        Motor Neurons that die are not as replaceable as muscle cells. Through one’s lifetime an individual can bulk up muscles, and lose them just as quickly, and over time replace them.  Neurons go through the Walerian degeneration where the axon tries to regrow and connect to the neuromuscular junction with the muscle to recover from injury. As long as the myelin sheath is intact, neurons can reconnect with muscle and skin that provide movement and sensory messages to/from the brain.

        It could be that the body’s signals to muscles triggering the natural loss of those muscles are getting mixing up with the signal to the neurons at the neuromuscular junction. Muscle cells reach the end of life much quicker than neurons do, so if the “switch” telling muscle cells to die is taken up by neurons they would terminate en mass (maybe thousands or hundreds of thousands at a time). Replacing muscles through diet and exercise is much faster than reinnervation. Reinnervation happens at about 1 inch/month, and if the nerve does not reach the neuromuscular junction within a limited timeframe, or is directed not to grow by dysfunctional signals, atrophy will become permanent. That ties into why I am most interested in NGF, nerve growth factor, and how it stimulates neuron growth.

        • #19441

          “Neurons cells are close cousins to muscle cells…”

          Motor Neurons that die are not as replaceable as muscle cells.

          That was true until a few years ago.

          But since 2017 at least, scientists are working in replacing motor neurons. Those scientists do not work in the ALS field, they work in the field of regenerative medicine. It’s a pity that ALS organizations do not fund heavily this field of medicine.

          This is even known form prominent ALS researchers. For example in June 2019 Don Cleveland suggested during a conference,
          that instead of inhibiting this or that ALS protein, ASOs could
          give rise to brand new neurons in a sick or aging brain
          . This is extremely important for pALS!

          This kind of research has already succeeded in reversing Parkinson’s disease in mice!

    • #19092
      Jim
      Participant

      Thank You Jean Rolzic! Hopefully I got that correct, JP Julien..
      Upregulation of INQLN2/Ubiquilin-2 are linked to pathology, mutants can form cytoplasmic aggregates. This Upregulation contributes to pathogenesis through NF-kappaB activation by p38 MAPK signaling.. Another words Inflammation.

    • #19449
      Duane
      Participant

      Burning coal creates toxins one of which is mercury. Its reasonable to assume some of it ends up in water in the area. Heavy metals like lead and mercury are most likely a factor as well as algae blooms. Leaded gas. And probably a variety of other things.

    • #19486
      Watti
      Participant

      Hi Jim …There have been concerns (in places other than the US ) about bodies of water ‘clusters’ and so-called ‘blue-green algae’= (not blue, or green, and it’s not algae, but anyway)- in bodies of water/ rivers, such as the large cluster on ONE side of a big lake in France…In Australia, we have the mysterious ‘cluster’ around an area sourced by a slow flowing river (Riverina cluster). So your theory about power stations and coal may only be true in one place- ? – or test for validity-as these others do not involve fossil fuel stations etc at this time.

      Or are you only looking at America? Have your read / heard of BMAA (the neurotoxin in Guam which caused an ALS like fatal illness to huge proportion of its ppn- turns out, BMAA IS (one of the neurotoxins produced by blue green algae / these watersupplies…But, the mechanism/ cause is not clear. It may be- correlation/ must be tested. AND there are other water-based neurotoxins, which at tiny amounts are not counted as harmful- but this needs reconsidering – I think that is about  to happen too.

      BTW, Great news about the dopamine agonist- (you mention in another post) – it’s already available for Restless Leg syndrome- just sayin’

      Best wishes

       

      Watti

       

       

      Melbourne

      Aust

      • #19501
        Dagmar Munn
        Keymaster

        … and then there are those pALS like me, who despite living in the dry, desert area – – nowhere near water, coal, or power lines still get ALS. Maybe it’s not always caused by environmental exposure.

    • #19496
      Kathy stitz
      Participant

      Unfortunately doctors don’t know what causes ALS, although there are many theories about what might cause it.  That’s one of the things that is so difficult about having ALS.  We don’t even know why we have it!  They need to have more of an understanding about what causes it in order to try to find a cure for it.

       

    • #19499
      Duane
      Participant

      And researchers need to do more comprehensive studies with long term survivors. Why some do better than others. Part of it I know is attitude towards the disease and it’s effects on you.  Fighters stand a better chance.

    • #19503
      Kathy stitz
      Participant

      I personally think a high level of exercise has something to do with it.  I have noticed that a lot of pALS have said they exercised a lot prior to being diagnosed with ALS.  Yesterday I read an interesting article about the relationship between exercise and ALS.  I don’t know how to put the article on here but it was called:  Strenuous Exercise Can Increase Your Risk Of ALS, Say Researchers.   It was written by Katie Spalding on June 11, 2021.  The researchers discovered that  regular, strenuous exercise is a risk factor for ALS.  They ruled out lifestyle factors like smoking, educational attainment and body fat percentage.   They don’t know why some people who exercise a lot get ALS but most do not.  The researchers state that exercise is beneficial for most people and most people who exercise a lot will not get ALS.  Now they need to try to find out why some people who exercise a lot get ALS but most don’t.   I guess this risk factor doesn’t apply in all cases of ALS and more studies are needed to find the causes of ALS and hopefully a cure soon!

       

       

       

       

       

      • #19505
        Dagmar Munn
        Keymaster

        Kathy – – I think you might have read it here in the forums 🙂 we have a discussion going in the Research Forum: https://alsnewstoday.com/forums/forums/topic/frequent-intense-exercise-is-a-risk-factor-for-als-but-is-it/

        Basically, it matters whether you have sporadic or genetic ALS. According to this study, we need to differentiate between the two (although the study’s title leads one to believe the risk is to ALL types of ALS). This study delves into the controversy surrounding theories that exercise (or sports) increases the risk of developing ALS in the first place. Remember, we’ve had over 10 years of published research showing the benefits of exercise once you’ve been diagnosed with ALS.

        You can read the full research article here: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00190-0/fulltext

        Snippets from the research findings:
        • For persons with genetic C9OIRF72 ALS: intense, strenuous, and competitive exercise may have been a causal risk factor for developing ALS.
        • But strenuous exercise was not a causal risk factor for those with sporadic ALS.
        • Likewise, sedentary behavior was not significantly associated with ALS. (So, a healthy, active lifestyle is still good to pursue)
        – DIY exercise, such as yoga, going for a walk, light workouts, etc. had no increased risk factor for developing ALS for either genetic or sporadic ALS – – it was the intense, strenuous kind, and then only a risk for those genetically predisposed to ALS.

        Other risk factors debunked in the study results
        • Body fat percentage is not significantly associated with ALS.
        • Neither is ALS associated with smoking, level of education, type 2 diabetes, or head trauma.

        The study’s authors propose that there is a functional link, “in which exercise amplifies toxicity resulting from a genetic mutation. Their study does not point to low-intensity, infrequent exercise having any risk of developing ALS, but does support toxicity resulting from high-intensity, frequent, leisure-time exercise.”

    • #19507
      Kathy stitz
      Participant

      Dagmar, thank you for the information.   I do recall reading that now.  What I was referencing was another article I had read about it that has similar information.

       

    • #19509
      Duane
      Participant

      Obviously it is not any one thing that causes it to develop over time.  The onset of major symptoms is like the tip of an iceberg where the rest of it has developed over years or decades.  First, I think there is a predisposition caused by a virus that does damage to the CNS. Then the disease progresses from there.  Think Polio, and Shingles where the virus resides in the nerves.  The symptoms of Post-Polio Syndrome are quite similar to ALS but usually with a lesser severity.

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